Endocrine Abstracts

Section 1: Case history: A 50-year-old woman presented to the HIV clinic after suspecting adverse effects following two intra-articular triamcinolone injections to her left hip, administered three and seven months prior. She complained of ongoing leg pain, generalised weakness and lethargy. Her past medical history included HIV infection, mild asthma for which she took inhalers only and had never required oral steroids. Her antiretroviral medications included dolutegravir, dar...

Section 1: Case history: A 78 years old lady presented to Emergency Department with two weeks history of lethargy and confusion. She had background of advanced destructive Rheumatoid Arthritis diagnosed 30 years ago, multiple joint fractures, osteoporosis, long-term urinary catheter, recurrent UTI and renal calculi. She was recently discharged from hospital for urosepsis. She was bed-bound for the last 15 years after crushing vertebrae C2 C3 pressing on spinal cord. Her regula...

Background: X-linked hypophosphatemia (XLH) is a rare, hereditary, progressive musculoskeletal disorder. Prompt diagnosis and treatment in childhood ensures adequate bone matrix mineralization and skeletal growth. There is no consensus on indications for treatment in adult patients.Case Presentation: A 25 year old female was referred to endocrinology with a right ankle fragility fracture. She was known to have XLH, diagnosed in Poland at the age of 1 yea...

Background: Diabetes Insipidus (DI) is uncommon during pregnancy. It may predate pregnancy, be unmasked by pregnancy or arise de novo during pregnancy secondary to other pathology. We present a case of DI in pregnancy to highlight challenges in management.Case Report: A 27-year-old lady at 21 weeks’ gestation, presented to A&E with worsening headache and confusion for three to five months. She was hemodynamically stable, had bitemporal hemianopi...

Background: HDR syndrome also known by the eponym Barakat syndrome, is a rare, autosomal dominant disorder characterized by the triad of hypoparathyroidism, sensorineural hearing loss, and renal abnormalities. It is caused due to mutation (haploinsufficiency) in GATA3 gene on chromosome 10p with a wide spectrum of phenotypic variations.Case Presentation: A 33-year-old lady presented to emergency department with an episod...

The dexamethasone suppression test (DST) is a common screening test in Cushing’s syndrome but associated with false positive result in 10-20%. One cause of false positivity is inadequate dexamethasone absorption. An assay to measure serum dexamethasone concentration can be used to validate the accuracy of the DST result.Aims: To audit 1) Use of the dexamethasone assay in DSTs 2) How frequently dexamethasone levels are inadequate 3) ...

Background: Duchenne muscular dystrophy (DMD) is a progressive muscle disorder characterised by muscle wasting and weakness. It is often associated with intracellular hypercalcaemia in dystrophin deficient muscle leading to disease progression. We present a comprehensive case report of extracellular hypercalcaemia in a DMD patient, a rare complication, emphasising the interplay of iatrogenic factors, immobilisation, and therapeutic approaches.<p class="abs...

Background: Hyponatremia is the most common electrolyte disorder encountered in clinical practice. Vulnerable cohorts tend to be hospitalised patients where it tends to occur in 15-20% of the patients and the other category being nursing home residents. Significant risk factors are increasing age, and polypharmacy.Aims: We aimed to look at the management of hyponatremia at our hospital, check adherence with the trust gui...

Glucose is the primary source of energy for cells and its levels are tightly regulated by the hormone insulin. In people with diabetes, the body either doesn’t produce enough insulin or doesn’t respond to insulin properly. Hyperglycemia can occur which carries high morbidity and mortality. Some common signs and symptoms include polyuria, polydipsia, polyphagia and fatigue. Diabetic ketoacidosis and hyperosmolar hyperglycaemic state are serious medical emergencies ass...

Neurosteroids are synthesized locally within the central nervous system and play essential roles in modulating neuronal activity and various brain functions. They can have a wide range of effects, including anxiolytic, sedative, analgesic, and neuroprotective actions. Understanding their distribution in the brain and how they interact with neurotransmitter systems is of significant interest to researchers studying brain function and related disorders. We aim to construct a 3D ...